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Simpson PB
flow cytometric analysis is used to detect the cell apoptosis both in SW620 cells and Cisp-resistant SW620 cells
PubMed Central PMCID: PMC5380531
C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20
Smiles: CC(C)(O)C(=O)N1CCN(CC1)C1=CC(C2=C(C3=CNC4=CC=CC=C43)C(=O)NC2=O)=C(C=C1)C(F)(F)F
GRP-60367 - CAS# 1309241-34-6 size:10mg solid Simpson PBGRP 60367, CAS No. 1309241 34 6, is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP 60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell to cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a
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