Sure it still dies when blocked by any one casting cost 1/1, but if your opponent stalled in getting out a blocker you could hit them with two damage instead of one
Collective Defiance This is a very odd card indeed but it gets plenty of play and seems to do its job pretty effectively
Azurite Sea also introduced a new Floodborn Rafiki, Ethereal Guide that has a whopping four lore value already, or you could use the new Good Job
Now the only way an opponent could evade infect damage would be to always have a chunk blocker ready, exile Plague Myr, or enchant it with a Pacifism-type aura to prevent it from attacking and blocking
Just be sure to prioritize killing their small Cinderellas so they can't shift out Cinderella - Stouthearted and remove him that way
This one is certainly for higher powered Cubes, but a discounted Gilded Lotus is most welcome there