ARRY-520 - CAS# 885060-09-3 azone Maleate Functional assays

Functional assays

Chemical Name: sodium2

Smiles: CC1NC(=O)NC(C=1C(=O)NC1C=C2C=NNC2=CC=1)C1C=CC(F)=CC=1

BG45 was used at 10 µM final concentration in various in vitro assays

Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases

ARRY-520 - CAS# 885060-09-3 azone Maleate Functional assaysFilanesib, also known as ARRY 520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY 520 specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic