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Even if what you target isnt that big, being able to draw three or four cards is already a considerable advantage

infect cards

When Alara was sundered millennia ago by an unknown Planeswalker, five shards of the world were separated and each developed their own unique cultures, cut off from two colors of mana

So, how does Think Twice do

Its great for getting rid of problematic enchantments, planeswalkers, or lands

Enigmatic Incarnation decks in Pioneer use a similar trick with cards like Overlord of the Floodpits and Leyline Binding that come down early to power out Overlord of the Hauntwoods or Atraxa, Grand Unifier