Each deck is pre-built and ready to play right out of the box
This means that whenever you cast a Human, you receive two Humans instead, functioning quite well with kindred-based cards that are more effective with large quantities of creatures
This means new copies of cards from older sets arent getting put into circulation, which makes them harder to find, especially in good condition, which raises the price
The only other main difference is that Commander damage is a thing
Be it choice of format, choice of play style or even choice of tokens, Johnny can use many different means to express himself
Door to Nothingness is a weaker, albeit iconic card due to its instant-win nature (and if you resolve it in a non-multiplayer game you'll instantly win)