For example, an opponent who gained 2 life and lost 1 life in the same turn still lost life
Mox Diamond lets you skip the land discard drawback in many decks by providing a zero-cost mana source in exchange for a land from hand
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Example Decklist: Niv to Light | Modern | fj_rodman, 5-0 MTGO League Creatures (10) 1 Valki, God of Lies 2 Birds of Paradise 3 Niv-Mizzet Reborn 4 Omnath, Locus of Creation Planeswalkers (10) 2 Nahiri, the Harbinger 4 Teferi, Time Raveler 4 Wrenn and Six Instants (14) 1 Kolaghan's Command 1 Prismari Command 2 Assassin's Trophy 2 Vanishing Verse 4 Kaya's Guile 4 Lightning Helix Sorceries (6) 1 Supreme Verdict 1 Unmoored Ego 4 Bring to Light Enchantments (8) 4 Abundant Growth 4 Utopia Sprawl Lands (47) 1 Island 1 Mountain 1 Plains 1 Swamp 2 Forest 1 Breeding Pool 1 Godless Shrine 1 Indatha Triome 1 Ketria Triome 1 Overgrown Tomb 1 Steam Vents 1 Stomping Ground 1 Temple Garden 2 Verdant Catacombs 3 Misty Rainforest 3 Pillar of the Paruns 3 Windswept Heath 3 Wooded Foothills 4 Prismatic Vista 1 Crumble to Dust 3 Fatal Push 3 Rest in Peace 1 Shadows' Verdict 4 Thoughtseize 2 Veil of Summer 1 Yorion, Sky Nomad 4

You can have a card like Bolas's Citadel or Ad Nauseam that lets you lose 20+ life in a turn and convert it into a giant Crackle with Power to win
Magic: The Gathering Squirrel Deck: Getting Squirrelly in Bloomburrow Limited By Vale Gauthier Hello, wafflers of the internet