Strangling Spores is a simple combination of numbers weve seen before (with a truly gruesome flavor) that will still be a solid spell, even if its not the most efficient or powerful version
Apart from mutate cards to trigger that ability, I guess you could use Stuffy Doll and Brash Taunter, or fill your deck with cards that grant abilities to your commander like backgrounds and the legendary familiars (Kediss, Falthis, et al)
Chart shows the price of 2 Pack Blister at the end of each month going back as long as we have tracked the item.
You want to hit them and double the rest of your damage for the turn, which can come from burn spells or from non first strike creatures that attacked alongside Lightning
This can even proc some of your other effects that trigger off of being destroyed
Its Pendulum effect allows its user to reduce the damage of one attack to 0 once per turn