With effects that range from slow, steady sources of damage that drain your opponent 1 life at a time to massive spells that consume half their life at once, theres a life loss card for any strategy
I do want to note a unique interaction red has with the life gain theme, which is that its big damage-dealing spells can be granted lifelink by either Judith, Carnage Connoisseur or Firesong and Sunspeaker if you want to get absolutely weird with it
Cards like K'rrik, Son of Yawgmoth and G'raha Tia, Scion Reborn offer powerful abilities that cost life to activate
Aside: this may be less true on Arena because of the ladder system emphasizing every match win
I think the idea is really cool, just the execution is not as good as Id like
But it's great in a few places - midrange where you have lots of bodies with black pips that are mugging up the board