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VS Mono-Red Aggro Out: In: Most red lists are spell-heavy enough that Duress is effective, but if yours is more creature-oriented Id leave in more creatures and potentially some Thoughtseizes if they have high-impact creatures like Goblin Chainwhirler

Will there be lessons to learn as we adapt to a new system

There are plenty of cards beyond these that will serve you well if youre drafting, and can be used in a few Commander decks too, but these ones are generally more useful across the board

Of note, Fortunes Favor targets and Saurons Ransom chooses, so you can choose an opponent with hexproof with the newer version

All in all, milling your opponent out isnt a particularly great strategy, and lets face it: there are much better cards youd want to play than Trepanation Blade

Although sideboard cards are always difficult to evaluate, I think Force has to be among the best five green cards in Modern