One of the biggest differences Ive noticed is time management: on MTGO you have your own clock, while in paper tournaments, the time is shared between both players
Paying 3W for a 1/1 flyer grievously fails the "vanilla test," and its pump effect just makes things worse
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The topic of exactly how many lands to run comes up pretty frequently among Commander players on my Twitter feed, so I can assure you that this is hardly a settled issue
What does trouble me is that I often see this infamous Beast forcefully waded into the power level discussion by high-power and combo players, asking how their way of winning is any different than someone laying down a Craterhoof
Another example is Aether Flash, which hits all creatures that enter the battlefield for two damage