It's okay to keep some non-inkable cards, like Dragon Fire or Della Duck, Unstoppable Mom, but a hand with too many uninkables is bound to run into problems in the early game
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You want to include cheap cantrips that accelerate you early followed by some bigger more powerful spells that bring destructive effects when copied
Not a lot, more like a 60/40 favor
Casting a spell that targets Brigone gives her a +1/+1 counter on top of whatever bonuses your spell would also give, helping her survive later into a match
Oh, wait - you can actually pay two extra mana to allow you to cast it as though it had flash, letting you play it at any time you could use an instant