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is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM
Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway
31)32/h2-6
induce differentiation of mesenchymal stem cells into cardiomyocytes
Preclinical Characterization of a Potent
LDN-57444 - Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor. CAS# 668467-91-2 Catalog No.:M60204-10S is a selective and potentLDN 57444, CAS No. 668467 91 2, is a novel potent and selective inhibitor of ubiquitin C terminal hydrolase L1 (UCH L1) with IC50 ~0. 88 M. It has ~28 fold greater selectivity over UCH L3 (ubiquitin C terminal hydrolase L3). LDN 57444 can increase levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. It causes cell death through the apoptosis pathway. LDN 57444s activity leads to dramatic alterations in synaptic protein
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