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InChi: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4
InChiKey: QAPAJIZPZGWAND-UHFFFAOYSA-N
JAK2 inhibitor AZD1480 inhibits JAK2 activation
Smiles: O=C(CCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)NC1=CC=C(CCC(=O)N2CCC2=O)C=C1
Smiles: NCCNC(=O)C1=CC=C(Cl)C=N1
Emavusertib - CAS# 1801344-14-8 ericin B InChi: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4Emavusertib, also known as CA 4948 is a potent IRAK4 FLT3 inhibitor with anti tumor activity. CA 4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA 4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with
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