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11-pentaene-6-carboxamide
Panarese JD
which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro
consistent with other published IAP inhibitors
Formula: C24H24N2O3S
NRX-252114 ncristine 11-pentaene-6-carboxamideNRX 252114 is a potent enhancer of the interaction between catenin, and its cognate E3 ligase, SCF TrCP. NRX 252114 enhances the binding of pSer33 S37A catenin peptide for TrCP with an EC50 of 6. 5 nM and a Kd of 0. 4 nM. NRX 252114 induces mutant catenin degradation. Product information Molecular Weight: 510. 32 Formula: C22H12Cl2F3N3O2S Chemical Name: 2 {4 [(2,6 dichlorophenyl)sulfanyl] 2 oxo 6 (trifluoromethyl) 1,2 dihydropyridine 3 carbonyl} 2,3