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GANT58 is a cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells)
InChiKey: LHIXVSSUGJJLKZ-VXKWHMMOSA-N
reduces basal levels of hepcidin expression and increasing serum iron concentrations in adult mice
Scriptaid enhances the response of human tumor cells to radiation
Drug Discov Today
Thalidomide-NH-PEG3-CH2CHO - CAS# 2360530-43-2 Catalog No.:M11569-2 GANT58 is a cell-permeable tetrapyridinylthiopheneThalidomide NH PEG3 CH2CHO is the Thalidomide based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide NH PEG3 CH2CHO can be connected to the ligand for protein by a linker to form PROTAC BCL XL degrader XZ739 (HY 133557). Product information CAS Number: 2360530 43 2 Molecular Weight: 447. 44 Formula: C21H25N3O8 Chemical Name: 2 {2 [2 (2 {[2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxo 2, 3 dihydro 1H isoindol 4