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InChiKey: GFARQYQBWJLZMW-JYFOCSDGSA-N
BRD9757 is absence of a surface-binding motif
and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
a significant and rapid reduction in leukemia burden was observed
with IC50s of 150 and 10 nM
MALT1-MI-2 (MI-2) - MALT1 inhibitor. CAS# 1047953-91-2 429 InChiKey: GFARQYQBWJLZMW-JYFOCSDGSA-NMALT1 MI 2 (MI 2), CAS No. 1047953 91 2, is a highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function. MI 2 concentrated within human ABC DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates with EC50 < 1 M (HBL 1 ~200 nM; TMD8 ~500 nM). This was accompanied by NF B pathway suppression, c REL nuclear localization inhibition, and NF B target gene downregulation. MI 2 was
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