1-Naphthyl 3, 5-dinitrobenzoate 15093 The racemic form Gossypol ((±)-Gossypol)

The racemic form Gossypol ((±)-Gossypol) binds to Bcl-xL protein with a Ki of 0

DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat

Barlerin also significantly increases vascularization compared with vehicle treatment

InChi: InChI=1S/C30H41N7OS/c1-39-28-21(3-2-8-32-28)16-34-29-35-17-24(14-31)27(37-29)36-18-30-11-20-9-22(12-30)26(23(10-20)13-30)33-15-19-4-6-25(38)7-5-19/h2-3

Smiles: C[C@]12CCCC(=C)[C@]1(O)C[C@@H](CC2)C(=C)C(O)=O

1-Naphthyl 3, 5-dinitrobenzoate 15093 The racemic form Gossypol ((±)-Gossypol)IC50: 1 and 3. 6 M for 5 lipoxygenase and microsomal prostaglandin E synthase 1, respectively 1 Naphthyl 3,5 dinitrobenzoate is a dual 5 lipoxygenase and microsomal prostaglandin E synthase 1 inhibitor. Human 5 lipoxygenase (5 LOX), a target for antiinflammation drug design, catalyzes the first two reactions in the production of leukotrienes from arachidonic acid (AA): oxygenation of AA to 5 HPETE and further dehydration to leukotriene A4 (LTA4). Then