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Tetrodotoxin is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels
PubMed PMID: 17312463
increasing the bioavailability of trifluiridine
and cell cycle arrest of MLL-AF6-transformed cells
It inhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of ~3 μM in vitro
AMG 487 - CAS# 473719-41-4 Catalog No.:M10194-2 Tetrodotoxin is a potent marine-derivedAMG 487 is a potent and selective antagonist of chemokine (C X C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8. 2nM for I IP 10 and I ITAC, respectively. AMG 487 prevents the chemokines I IP 10 and I ITAC from binding to CXCR3. In the cellular assays, AMG 487 inhibits CXCR3 mediated cell migration with IC50 values of 8nM, 15nM and 36nM for I IP 10, I ITAC and MIG, respectively. Product information CAS Number: 473719 41 4 Molecular Weight:
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