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279(13):12876-82
16)14-8-4-3-5-9-14/h6-7
131(8):1735-44
InChi: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14
GSK591 A chemical probe for PRMT5
AZD2014 - mTOR Inhibitor. CAS# 1009298-59-2 size:2 mg solid 279(13):12876-82AZD2014, CAS No. 1009298 59 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 2. 8 nM). It displays a high level of selectivity against other members of the PIKK family (IC50 against PI3K isoforms , , , = 3. 8 M, >30 M, >30 M and >29 M, respectively) and is inactive against a general panel of over 200 kinases when tested at 10 M. AZD2014 inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235 236 ) IC50 = 0. 2 M, pAKT (S473) IC50
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