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18(4):531-41
PubMed PMID: 27607364
and -9-mediated cascades are involved in this mechanism
Chemical Name: 4'-((1S
Janus-Associated Kinase Inhibitor I
GNE-7915 - CAS# 1351761-44-8 0254 18(4):531-41GNE 7915, CAS No. 1351761 44 8, is a potent LRRK2 kinase inhibitor, which possess an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. GNE 7915 was reported as a potent (IC50=9 nM) selective (1 187 kinases), brain penetrant and non toxic inhibitor of LRRK2. Product information CAS Number: 1351761 44 8 Molecular Weight: 443. 40 Formula: C19H21F4N5O3 Synonym: GNE 7915
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