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The IC50 for the human RNA polymerase II is 905 μM
pii: S0031-9384(16)30416-4
IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression
The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib
Formula: C22H23N7O
MERcK-5 - CAS# 457081-03-7 Catalog No.:M6539-2 The IC50 for the humanPyridone 6, also known CMP 6 or JAK Inhibitor I, CAS No. 457081 03 7, is a pan Janus activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down regulation of receptor activator of nuclear factor kappaB (NF kappaB) ligand (RANKL) induced c
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