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UMB-32 Catalog No.:M22476-C Smiles: NCC1=CC2CN(C3CCC(=O)NC3=O)C(=O)C=2C=C1

SKU: 92385926203

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Description

Smiles: NCC1=CC2CN(C3CCC(=O)NC3=O)C(=O)C=2C=C1

Chemical Name: (3Z)-3-[(2-methoxyphenyl)methylidene]-2

GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM

Solubility: DMSO : 100 mg/mL (229

InChi: InChI=1S/C7H16NO2

UMB-32 Catalog No.:M22476-C Smiles: NCC1=CC2CN(C3CCC(=O)NC3=O)C(=O)C=2C=C1UMB 32 is a potent, selective inhibitor of the BET bromodomain BRD4 . The BET family (BRD2, BRD3, BRD4, and BRDT) functions as transcriptional coactivator proteins. BET bromodomains are also important mediators of cell cycle progression and facilitate developmental transitions such as spermiogenesis. Deregulation of BET bromodomain function has been observed in numerous malignancies. BET bromodomain inhibition has contributed new insights into gene

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