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and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells
CAS Number: 1379686-29-9
a Highly Selective Protein Interaction Inhibitor
Blockade of mutant IDH1 impaired the growth of IDH1-mutant—but not IDH1-wild-type—glioma cells without appreciable changes in genome-wide DNA methylation
It inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity
GSK-J4 - H3K27 Histone Demethylases UTX and JMJD3 Inhibitor. CAS# 1373423-53-0 0003 and fitness of both humanGSK J4, CAS No. 1373423 53 0, is an ethyl ester derivative of GSK J1, which is the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3. The highly polar carboxylate group of GSK J1 restricts its cellular permeability, therefore GSK J4 was developed as a pro drug, masking the polarity of the acid group of the GSK J1, for cellular assays. GSK J4 could significant reduce LPS induced pro inflammatory cytokine production in
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