PT 1 Catalog No.:M23080-C CB-103 produces Notch loss-of-function phenotypes

CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts

which may be mediated by ABCG2

Chemical Name: dimethyl({2-[(2-methylphenyl)(phenyl)methoxy]ethyl})amine hydrochloride

Significant deficits are observed after treatment with 2

with an ED50 of 35 μmol/kg measured 1 h postdosing

PT 1 Catalog No.:M23080-C CB-103 produces Notch loss-of-function phenotypesPT 1 is a selective activator of AMPK with EC50 value of 0. 3 M for AMPK 111 . AMP activated protein kinase (AMPK) is serine threonine protein kinase that involved in cellular energy homeostasis and acts as an energy sensor. AMPK is a heterotrimer and increases ATP generation . PT 1 is a selective AMPK activator. PT1 activated human AMPK 1394, AMPK 2398 and AMPK(111) with EC50 values of 8, 12 and 0. 3 M, respectively. PT1 exhibited maximum activity