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extracted from patent WO 2016041489 A1
the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617
1007/978-981-10-3233-2_15
MBC-11 shows similar activity profiles and significantly inhibits growth of all three cell lines between 10-8 and 10-4 M
InChi: InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11
Bictegravir 51322 extracted from patent WO 2016041489Bictegravir (GS 9883) is a potent inhibitor of HIV 1 integrase with an IC50 of 7. 5 nM. Product information CAS Number: 1611493 60 7 Molecular Weight: 449. 38 Formula: C21H18F3N3O5 Chemical Name: (1S,11R,13R) 5 hydroxy 3,6 dioxo N [(2,4,6 trifluorophenyl)methyl] 12 oxa 2,9 diazatetracyclo[11. 2. 1. 0,. 0,]hexadeca 4,7 diene 7 carboxamide Smiles: OC1=C2C(=O)N3[C@@H](CN2C=C(C(=O)NCC2C(F)=CC(F)=CC=2F)C1=O)O[C@H]1C[C@@H]3CC1 InChiKey: SOLUWJRYJLAZCX
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