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11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6
In vivo experiments using the KM12-bearing mouse xenograft model shows that DS-6051b induced tumor shrinkage at a ≥50 mg/kg or higher treatment dose without significant body weight loss
InChiKey: VIKNJXKGJWUCNN-XGXHKTLJSA-N
57 nmol/L)
CAS Number: 1337883-32-5
PF-3644022 Catalog No.:M12254-2 11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6PF 3644022 is a potent, selective, orally active and ATP competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5. 2 nM and a Ki of 3 nM. PF 3644022 also inhibits MK3 and p38 regulated activated kinase (PRAK) with IC50s of 53 nM and 5. 0 nM, respectively. PF 3644022 potently inhibits TNF production and has anti inflammatory effect. Product information CAS Number: 1276121 88 0 Molecular Weight: 374. 46 Formula: C21H18N4OS Chemical Name: (15R) 15 methyl 5
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