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LY294002 inactivates Akt/PKB
is an inhibitor of MDM2 (human homolog of murine double minute 2)
PubMed PMID: 23721803
Giannetti AM
Stachowicz A
SQ109 Size:Solid 2 mg LY294002 inactivates Akt/PKBSQ109 is a drug undergoing development for treatment of tuberculosis. SQ109 showed activity against both drug susceptible and Multi drug resistant tuberculosis bacteria, including Extensively drug resistant tuberculosis strains. In preclinical studies SQ109 enhanced the activity of anti tubercular drugs isoniazid and rifampin and reduced by >30% the time required to cure mice of experimental TB. SQ109 is being developed by OOO Infectex in Russia and
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