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AD57 potently dampened the pathway-related human kinases B-Raf
Under normal conditions
InChi: InChI=1S/C12H13N4O4S
Pfaffendorf M
Smiles: O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O
CU-3 aflumizone AD57 potently dampened the pathway-relatedCU 3 is the racemate of (5Z,2E) CU 3. (5Z,2E) CU 3 is a potent and selective inhibitor against the isozyme of DGK with an IC50 value of 0. 6 M, competitively inhibits the affinity of DGK for ATP with a Km value of 0. 48 mM. (5Z,2E) CU 3 targets the catalytic region, but not the regulatory region of DGK. (5Z,2E) CU 3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells. Product information CAS
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