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and good permeability in the Caco-2 cell assay
It does so through the downregulation of the synthesis of cyclin D1
InChi: InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15
It is clinically tested for its role in the treatment of left ventricular systolic heart failure
The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055
Ledipasvir - CAS# 1256388-51-8 0153 and good permeability in theLedipasvir, also known as GS 5885, CAS No. 1256388 51 8, is an inhibitor of the hepatitis C virus NS5A protein and is a drug for the treatment of hepatitis C that was developed by Gilead Sciences. On October 10, 2014 the FDA approved the combination product ledipasvir 90 mg sofosbuvir 400 mg (trade name Harvoni). The ledipasvir sofosbuvir combination is a direct acting antiviral agent that interferes with HCV replication and can be used to treat
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