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6-fold resistant to crenolanib
Chemical Name: propan-2-yl (2S)-2-{[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]amino}propanoate
InChi: InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8
PubMed Central PMCID: PMC3706837
and exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide
Panobinostat abolite Omeprazole sulfone 6-fold resistant to crenolanibPanobinostat, also known as NVP LBH 589 or LBH 589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2 M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis related genes, such
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