Glucocorticoid receptor agonist-1 Size:Contact [email protected] for quotation 48 hours) inhibits BTK-transformed Ba/F3

48 hours) inhibits BTK-transformed Ba/F3 cell proliferation with an IC50 of 11

[O-]C(=O)[C@H]1C[C@@H]1C(=O)C1C=CC(Cl)=C(Cl)C=1

1-3H3/t15-/m1/s1

Smiles: CC(C)C[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC3=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N2)[C@@H](C)O)[C@@H](C)O

and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases

Glucocorticoid receptor agonist-1 Size:Contact [email protected] for quotation 48 hours) inhibits BTK-transformed Ba/F3Glucocorticoid receptor agonist 1 is a potent glucocorticoid receptor agonist with an IC50 of 2. 8 nM extracted from patent WO2017210471A1, compound 41. Product information CAS Number: 2166375 82 0 Molecular Weight: 569. 69 Formula: C35H39NO6 Chemical Name: (1S,2S,4R,6R,8S,9S,11S,12S,13R) 6 {4 [(3 aminophenyl)methyl]phenyl} 11 hydroxy 8 (2 hydroxyacetyl) 9,13 dimethyl 5,7 dioxapentacyclo[10. 8. 0. 0,. 0,. 0,]icosa 14,17 dien 16 one Smiles: