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induces DNA double-strand breaks quantified as S139 phosphorylated histone foci (γ-H2AX) and Comet tails induced in MDA-MB-231 cells
The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation
Smiles: CC(C)NCCN1C2=CC=C(C=C2C2=CC(=CC=C12)C(C)=O)C(C)=O
Hammitzsch A
Impellizzeri AA
Bortezomib entane induces DNA double-strand breaks quantifiedHigh affinity proteasome inhibitor (Ki = 0. 6 nM). Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines. Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs). Acts synergistically with dexamethasone (Cat. No. 1126). Also cytotoxic in MCF 7 breast cancer cell line (IC50 = 50 nM). Product information CAS
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