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In mouse xenograft models of NHL
The inhibitory effect of the lowest concentration (5 nM) of JYL 1421 reaches the level of significance and 1 μM almost abolishes the response
44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8
Rat and monkey t1/2 values for siponimod (another S1P1 modulator currently in human trials) have been disclosed and are 6 and 19 h
indicating that vinflunine may exhibit reduced neurotoxicity
Ro 04-5595 hydrochloride n dimyristate In mouse xenograft models ofProduct information CAS Number: 64047 73 0 Molecular Weight: 368. 30 Formula: C19H23Cl2NO2 Chemical Name: (1R,2S) 1 [2 (4 chlorophenyl)ethyl] 7 hydroxy 6 methoxy 2 methyl 1,2,3,4 tetrahydroisoquinolin 2 ium chloride Smiles: [Cl ]. COC1C=C2CC[N@H+](C)[C@H](CCC3C=CC(Cl)=CC=3)C2=CC=1O InChiKey: NVIPBLQAFKRFSZ UNTBIKODSA N InChi: InChI=1S C19H22ClNO2. ClH c1 21 10 9 14 11 19(23 2)18(22)12 16(14)17(21)8 5 13 3 6 15(20)7 4 13; h3 4,6 7,11 12,17,22H,5,8
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