JAK2/FLT3-IN-1 TFA 13224 male athymic nude mice) treatment

male athymic nude mice) treatment results in a significant inhibition of tumor growth

and PKC with 1000-fold or greater IC50 values

Smiles: CC(C)C(NC(=O)C(CC(O)=O)NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)C1CCCN1C(=O)C(N)CC1C=CC(O)=CC=1)C(=O)N1CCCC1C(=O)NC(CC(O)=O)C(=O)NC(CC1C=CC(O)=CC=1)C(=O)NC(C)C(O)=O

InChi: InChI=1S/C17H26N2O4S

Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCC#C)C(C)(C)C)=CC=1

JAK2/FLT3-IN-1 TFA 13224 male athymic nude mice) treatmentJAK2 FLT3 IN 1 (TFA) is a potent and orally active dual JAK2 FLT3 inhibitor with IC50 values of 0. 7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2 FLT3 IN 1 (TFA) has anti cancer activity. Product information CAS Number: 2928093 29 0 Molecular Weight: 581. 61 Formula: C27H35F4N7O3 Chemical Name: 2 ({1 [2 fluoro 4 ({5 methyl 4 [1 (propan 2 yl) 1H pyrazol 4 yl]pyrimidin 2 yl}amino)phenyl]piperidin 4 yl}(methyl)amino)ethan 1