hSMG-1 inhibitor 11e DE-IN-2 orally active and highly selective

orally active and highly selective EGFR inhibitor with a Ki of 0

0 M Sucrose solutions less during HE-feeding relative to chow-feeding (P=0

Smiles: CC1(C)[C@@H]2CC[C@]3(C)[C@H](CC=C4[C@H]5[C@](CC[C@@H](C)[C@@]5(C)O)(CC[C@@]34C)C(=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@]2(C)CC[C@@H]1O[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O

Tosylchloramide may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites

50 µM and 1

hSMG-1 inhibitor 11e DE-IN-2 orally active and highly selectivehSMG 1 inhibitor 11e is a potent and selective hSMG 1 kinase inhibitor with an IC50 of <0. 05 nM. hSMG 1 inhibitor 11e shows >900 fold selectivity over mTOR (IC50 of 45 nM), PI3K (IC50s of 61 nM and 92 nM) and CDK1 CDK2 (IC50s of 32 M and 7. 1 M). Product information CAS Number: 1402452 10 1 Molecular Weight: 517. 60 Formula: C26H27N7O3S Chemical Name: 1 {4 [4 (2 {[3 (dimethylsulfamoyl) 4 methylphenyl]amino}pyrimidin 4 yl)pyridin 2 yl]phenyl} 3