BIIB021 D5 Dazoxiben inhibits TXB2 production in

Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1

InChi: InChI=1S/C21H16FN3OS

but instead correlated with inhibition of casein kinase 1 (CK1) in vitro

Leflunomide prevents the expansion of activated and autoimmune lymphocytes by interfering with the cell cycle progression due to inadequate production of rUMP and utilizing mechanisms involving p53

Formula: C32H26N8O2S

BIIB021 D5 Dazoxiben inhibits TXB2 production inBIIB021, also known as CNF2024, is an orally active, purine scaffold, small molecule inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90 inhibitor CNF2024 specifically blocks active HSP90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this may result in the inhibition of cellular proliferation in susceptible tumor