22(R)-hydroxy Cholesterol Catalog No.:M22746-C 30 minutes) causes sustained decrease

30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes

E6446 (20 mg/kg

InChiKey: MYRPIYZIAHOECW-SAIXKJTDSA-N

Smiles: CN1C2N=C(OC3C=C(C=CC=3)OC(F)(F)F)N(CC3=CC=C(Cl)C=C3)C=2C(=O)N(CCCO)C1=O

Kowalska E

22(R)-hydroxy Cholesterol Catalog No.:M22746-C 30 minutes) causes sustained decreaseEC50: 325 nM 22(R) hydroxy cholesterol is an endogenous agonist for liver X receptors (LXRs). The liver X receptors, LXRR and LXR, together with the farnesoid X receptor, FXR, form a subfamily of these orphan receptors. Recently, it has been reported that LXR and FXR are hormone receptors for oxysterols and bile acids, respectively. In vitro: Previous study found that 22(R) hydroxycholesterol was only found in the adrenals as an intermediate in