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InChi: InChI=1S/C30H60N3O3
Reserpine hydrochloride at doses of 0
16(4):601-8
Abemaciclib inhibits the proliferation of the parental A375 and resistant A375RV1 and A375RV2 cells with similar potencies with IC50 values of 395
5-3(6)1-2-4(7)8/h6-9
PF-5274857 773 InChi: InChI=1S/C30H60N3O3PF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for
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