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Brusatol (NSC 172924) also inhibits Nrf2 in freshly isolated primary human hepatocytes
as a sulfhydryl group reagent
EN4 directly targets MYC in cells and reduces MYC and MAX thermal stability
InChi: InChI=1S/C19H39NO/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(21)20-18(2)3/h18H
Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3
Indomethacin-D4 10844 Brusatol (NSC 172924) also inhibitsIndomethacin D4 (Indometacin D4) is a deuterium labeled Indomethacin. Indomethacin is a potent, blood brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX 1 and COX 2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes. Product information CAS Number: 87377 08 0 Molecular Weight: 361. 81 Formula: C19H16ClNO4 Chemical Name: 2 {1 [4
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