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Smiles: COC1=CC(=NC(NC(=O)NS(=O)(=O)C2=NC=CC=C2C(=O)N(C)C)=N1)OC
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
and orally active inhibitor of p38α MAPK with a Ki of 101 nM
InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4
High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1
Palbociclib-propargyl 314entane-1 5-diamine dihydrochloride Smiles: COC1=CC(=NC(NC(=O)NS(=O)(=O)C2=NC=CC=C2C(=O)N(C)C)=N1)OCPalbociclib propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP 10. CP 10 shows a DC50 of 2. 1 nM for CDK6. Product information CAS Number: 2366269 23 8 Molecular Weight: 485. 58 Formula: C27H31N7O2 Chemical Name: 6 acetyl 8 cyclopentyl 5 methyl 2 ({5 [4 (prop 2 yn 1 yl)piperazin 1 yl]pyridin 2 yl}amino) 7H,8H pyrido[2,3 d]pyrimidin 7 one Smiles:
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