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Phthalimide-PEG4-PDM-OTBS CT007093 Cucurbitacin I induces a concentration-dependent

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Description

Cucurbitacin I induces a concentration-dependent decrease in Stat3 expression whereas P-Stat3 is undetectable

modulates Th1 differentiation in CD4(+) T cells from patients with rheumatoid arthritis

PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group

Structural studies revealed that the tert-butyl amine of UNC2170 anchors the compound in the methyl-lysine (Kme) binding pocket of 53BP1

InChi: InChI=1S/C63H98O30/c1-25-46-47(89-51-43(77)38(72)29(67)21-82-51)45(79)53(85-25)91-48-39(73)30(68)22-83-54(48)93-56(80)63-14-13-57(2

Phthalimide-PEG4-PDM-OTBS CT007093 Cucurbitacin I induces a concentration-dependentPhthalimide PEG4 PDM OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide PEG4 PDM OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin proteasome system to selectively degrade target proteins. Product information Molecular Weight: 536. 73

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