Cathepsin G Inhibitor I 16895 2-oxazole-3-carbohydrazide

2-oxazole-3-carbohydrazide

0001) and 627±248 mm3 for T24 xenografts treated with 20 mg/kg (P<0

1'-biphenyl]-4-yl}ethoxy)pyrimidin-4-yl]phenyl}propanoic acid

LNCaP prostate cancer and HCT-116 colon cancer

ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11

Cathepsin G Inhibitor I 16895 2-oxazole-3-carbohydrazideIC50: 53 nM Cathepsin G (EC 3. 4. 21. 20, chymotrypsin like proteinase, neutral proteinase) is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non peptide inhibitor of cathepsin G. In vitro: Cathepsin G Inhibitor I shows reversible, competitive inhibition with IC50 and Ki values of 53 12 (N = 10) and 63 14 nM (N = 5),