CAL-130 Hydrochloride - CAS# 1431697-78-7 60153 full IC50 determinations is performed

full IC50 determinations is performed for VU0364770 at the MAO-A and MAO-B isoforms

Smiles: CC(C)S(=O)(=O)C1=CC2C(C=C1)=NC=CC=2NC1C=C2N=CSC2=CC=1

Formula: C27H28N6O2

Kadoshima T

In a recent study of pancreatic explants

CAL-130 Hydrochloride - CAS# 1431697-78-7 60153 full IC50 determinations is performedCAL 130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3 kinase (PI3K) Akt activation is common in T cell acute lymphoblastic leukemia (T ALL). Although four distinct class I PI3K isoforms (, , , ) could participate in T ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3K or PI3K alone can support