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FPS-ZM1 inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain
InChiKey: VUNOFAIHSALQQH-UHFFFAOYSA-N
MLN8237 is currently in Phase II study for treatment of patients with ovarian
which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma
PubMed Central PMCID: PMC4292866
Exatecan Mesylate - CAS# 169869-90-3 0271 FPS-ZM1 inhibits RAGE-mediated influx ofExatecan Mesylate, CAS No. 169869 90 3, also known as DX 8951, is semisynthetic, water soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater
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