TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM)
Smiles: CN1C(=O)N[C@@H](CC1=O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(N)=O
Chemical Name: N-Methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide monohydrochloride
both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current
a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch
Diethyltoluamide Catalog No.:M19402-C TH588 hydrochloride is first-in-class nudixDiethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. Product information CAS Number: 134 62 3 Molecular Weight: 191. 27 Formula: C12H17NO Chemical Name: N,N diethyl 3 methylbenzamide Smiles: CC1C=CC=C(C=1)C(=O)N(CC)CC InChiKey: MMOXZBCLCQITDF UHFFFAOYSA N InChi: InChI=1S C12H17NO c1 4 13(5 2)12(14)11 8 6 7