OT-R antagonist 1 798rterolane 11aS)-1-ethynyl-1-hydroxy-11a-methyl-1H

11aS)-1-ethynyl-1-hydroxy-11a-methyl-1H

Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer

InChi: InChI=1S/C16H19NO3/c1-19-12-3-2-10-9-17-7-6-16-5-4-11(18)8-13(16)20-15(12)14(10)16/h2-5

Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport

143621-35-6

OT-R antagonist 1 798rterolane 11aS)-1-ethynyl-1-hydroxy-11a-methyl-1HOT R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT R antagonist. OT R antagonist 1 inhibits oxytocin evoked intracellular Ca2+ mobilization (IC50 = 8 nM). IC50 value: 8 nMTarget: oxytocin receptorin vitro: OT R antagonist 1 inhibitis IP3 Synthesis, rat OT R (IC50=0. 03 uM). OT R antagonist 1 inhibits phosphodiesterase IV with IC50 = 6. 1 M, a value about 300 fold higher than the affinity for OT R. OT R antagonist 1