AST-1306 990 Chemical Name: N-ethyl-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide

Chemical Name: N-ethyl-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide

2014 Oct 9

and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)

TGX-221 is a potent

Atipamezole alters the behavioural effects of pramipexole and increases pramipexole concentration in blood plasma

AST-1306 990 Chemical Name: N-ethyl-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamideAllitinib, also known as AST1306 and ALS 1306, is a potent, selective, irreversible ErbB2 and EGFR inhibitor. AST 1306 inhibits the enzymatic activities of wild type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell free and cell based systems. AST1306 was found to function as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and