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Chemical Name: 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride
Targeting BET Bromodomains
Kitanaka C
without affecting spontaneous HPV-specific CD8(+) T cell responses
Smiles: CC1C=C(C=C(C)C=1CC1=CC=C(O)C(=C1)C(C)C)OCP(O)(O)=O
LB-100 Catalog No.:M8527-10 Chemical Name: 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochlorideLB 100 is a protein phosphatase 2A(PP2A)inhibitor. LB 100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. LB 100 enhanced the effects of sorafenib in HCC cells only during hypoxic environments. LB 100 dramatically increased intracellular p Smad3 level, which was responsible for the effect of LB 100 as a sensitizer. LB 100 downregulated Bcl 2 expression and enhanced sorafenib
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