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inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2
Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery
InChi: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13
Smiles: CC(=O)C1C2C3=C4C(CC1(C)O)=C(OC)C(=O)C1C4=C(C4=C3C(C(=O)C=2OC)=C(O)C=C4OC)C(=CC=1O)OC
Molecular Weight: 750
Flupirtine Maleate 0099 inhibited cell proliferation (IC50 =Flupirtine, also known as W 2964, is an aminopyridine that functions as a centrally acting non opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non opioid, non NSAID, non steroidal centrally acting analgesic. Flupirtine is a selective neuronal potassium channel opener that also
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