6-Mercaptopurine Catalog No.:M8131-10 Approximately 26-32% of the iv

Approximately 26-32% of the iv dose of PF-06282999 is excreted in the unchanged form in rat

Brekken RA

InChiKey: PDMUGYOXRHVNMO-UHFFFAOYSA-N

and similar potency was observed for EZH2 proteins bearing all known lymphoma change-of-function mutations

PBIT was used at 10-30 µM in vitro

6-Mercaptopurine Catalog No.:M8131-10 Approximately 26-32% of the ivMercaptopurine is a thiopurine derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6 thioguanosine 5' phosphate (6 thioGMP) and 6 thioinosine (T IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA